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The study "The Toxicity of Caffein: An Experimental Study on Different Species of Animals" by William Salant and John Benjamin Rieger explores the effects of caffein on various animal species, including rabbits, guinea pigs, cats, and dogs. The research aims to determine the minimum toxic and lethal doses of caffein when administered through different methods such as subcutaneous, oral, intramuscular, and intravenous injections. The study highlights the variability in response to caffein across different species and even within the same species, influenced by factors such as diet, race, and individual health conditions. For instance, Belgian hares demonstrated greater resistance to caffein compared to other rabbit varieties. The experiments revealed that approximately 150 mg of caffein per kilogram is the minimum dose that produces symptoms of nervous irritability in rabbits when injected subcutaneously. However, doses around 200 mg per kilogram were often fatal, especially in non-Belgian hare rabbits. The study also notes that diet, such as feeding carrots instead of oats, did not significantly alter the toxicity of caffein, suggesting that genetic factors might play a more prominent role. The research underscores the importance of considering species-specific responses and individual variability when assessing the toxicity of substances like caffein.

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